Akira Shinohara

The paper maps the spatial distribution of DSB proteins in yeast and mouse, revealing distinct assembly pathways and long-range control mechanisms that shape DSB landscapes.

This study shows that RAD51 accumulates on non-damaged chromosomes in aging oocytes, leading to chromosome segregation failure and meiosis I arrest.

This study identifies Arg97 and Arg117 in Mei5 as critical for complex formation and post-translational processing in yeast meiosis.

This study shows RPA is essential for maintaining the meiotic recombination checkpoint in yeast by sensing ssDNA and activating Mek1 kinase to regulate pachytene exit.

This study shows FIGNL1 regulates RAD51/DMC1 filament dynamics in meiotic recombination by dismantling non-productive assemblies during pre-meiotic S-phase and meiotic prophase I.

This study identifies phosphorylation of Mps3's luminal region as critical for its nuclear envelope localization during meiosis, mediated by CDK and DDK.

This study shows Exo1 protects DNA nicks to promote meiotic crossover formation and distribution in budding yeast.

This study shows that the Ecm11-Gmc2 complex modulates crossover pathways and suppresses non-crossover recombination during meiosis in budding yeast.

This study shows that SCFCdc4 ubiquitin ligase regulates synaptonemal complex formation during meiosis, collaborating with Pch2 and affecting meiotic recombination.

The paper investigates the in vivo localization of Msh5 during meiosis in yeast, showing its association with DSB hotspots, chromosome axis, and centromeres, and its role in promoting crossover formation.

This study shows that Rad24/Rad17 and Mec1/ATR have distinct roles in regulating meiotic crossovers, with Rad24 affecting CO frequency on shorter chromosomes and Mec1 impacting CO interference.

This study identifies SWSAP1 as a regulator of RAD51 filament formation by inhibiting the anti-recombinase FIGNL1, which dismantles RAD51 from ssDNA.