Intracranial electrophysiology reveals distinct neural representations of nociception and salience in the human brain
Siddhartha Joshi, Mensure Polat, Sofia Pantis, Ritika Garg, Salaar Ahmed, Yuhao Huang, Paul D. McGeoch, Corey J. Keller, Vivek Buch, Sean Mackey, Josef Parvizi, Ashwin G. Ramayya
The paper uses intracranial recordings to show that nociception and salience have distinct neural representations in the human brain, with different anatomical, temporal, and functional characteristics.
bioRxiv · Oct 8, 2026 · PreprintNeuroscience