A switch from histone methyltransferase-EZH2 to demethylase KDM6A activity marks reinitiation of proliferation of drug treated colorectal cancer cells
Subhashree Chatterjee, Ritika Jaiswal, Aniruddha Roy, Shibasish Chowdhury, Sudeshna Mukherjee, Rajdeep Chowdhury
This study shows that drug-treated colorectal cancer cells switch from EZH2-mediated repression to KDM6A-mediated activation, enabling reinitiation of proliferation and tumor relapse.
bioRxiv · Nov 4, 2025 · PreprintCancer Biology