Rajdeep Chowdhury

KDM6A Loss Confers an Invasive Phenotype in Osteosarcoma by Activating Cytoplasmic YAP-Dependent β-catenin Stabilisation

This study shows that KDM6A loss promotes invasive osteosarcoma by activating cytoplasmic YAP-dependent β-catenin stabilization.

Cisplatin-induced oxidative stress regulates YAP to modulate epigenome promoting survival of osteosarcoma cells

This study shows that cisplatin induces oxidative stress, leading to epigenetic repression via YAP and promoting osteosarcoma cell survival.

DRP1-mediated mitochondrial dynamics orchestrate EMT in glioblastoma cells

This study shows that DRP1-mediated mitochondrial fission and spatial dynamics regulate EMT in glioblastoma cells, with implications for therapeutic strategies.

A switch from histone methyltransferase-EZH2 to demethylase KDM6A activity marks reinitiation of proliferation of drug treated colorectal cancer cells

This study shows that drug-treated colorectal cancer cells switch from EZH2-mediated repression to KDM6A-mediated activation, enabling reinitiation of proliferation and tumor relapse.

LncRNA YIYA enhances pancreatic cancer proliferation under high-glucose conditions through RAS and PKM2 mediated metabolic reprogramming that reinforces the Warburg phenotype

This study identifies lncRNA YIYA as a glucose-responsive factor in pancreatic cancer that promotes proliferation via RAS and PKM2-mediated metabolic reprogramming, enhancing the Warburg effect.

Chloroquine attenuates hypoxia-mediated autophagy to curb thrombosis- an ex vivo and in vivo study

This paper shows chloroquine inhibits hypoxia-induced autophagy in platelets, reducing thrombosis in both ex vivo and in vivo models.