Fluvoxamine maleate ameliorates Alzheimer disease pathology by mitigating amyloid-beta load and neuroinflammation in 5XFAD mice
Sukhleen Kaur, Kuhu Sharma, Ankita Sharma, Kamalpreet Kaur Sandha, Syed Mudassir Ali, Riyaz Ahmed, P. Ramajayan, Parvinder Pal Singh, Zabeer Ahmed, Ajay Kumar
This study shows that fluvoxamine maleate reduces Alzheimer's pathology in 5XFAD mice by clearing amyloid-beta and inhibiting neuroinflammation through autophagy and NLRP3 inflammasome suppression.
bioRxiv · Dec 17, 2023 · PreprintNeuroscience