Minoxidil hydrochloride impedes NLRP3 inflammasome activation via upregulation of AMPK-mediated autophagy
Sukhleen Kaur, Mehboob Ali, Anjum Shafeeq, Ziya Tufail, Lakhvinder Singh, Zabeer Ahmed, Ajay Kumar
This study identifies minoxidil hydrochloride as an inhibitor of the NLRP3 inflammasome, showing reduced IL-1β and IL-18 secretion in cell and mouse models.
bioRxiv · Oct 16, 2026 · PreprintImmunology