Ajay Kumar

Minoxidil hydrochloride impedes NLRP3 inflammasome activation via upregulation of AMPK-mediated autophagy

This study identifies minoxidil hydrochloride as an inhibitor of the NLRP3 inflammasome, showing reduced IL-1β and IL-18 secretion in cell and mouse models.

Bisdemethoxycurcumin mitigates Alzheimer disease pathology through autophagy-mediated reduction of senescence and amyloid beta

This study shows that BDMC improves AD pathology by enhancing autophagy, reducing senescence, and lowering amyloid beta in both astrocytes and a mouse model.

Fluvoxamine maleate ameliorates Alzheimer disease pathology by mitigating amyloid-beta load and neuroinflammation in 5XFAD mice

This study shows that fluvoxamine maleate reduces Alzheimer's pathology in 5XFAD mice by clearing amyloid-beta and inhibiting neuroinflammation through autophagy and NLRP3 inflammasome suppression.