Targeting eIF2α in TBI-induced traumatic optic neuropathy: Effects of Salubrinal and the Integrated Stress Response Inhibitor.
Shelby M. Hetzer, Rohan Bellary, Jordyn N. Torrens, Robert F Grimaldi, Nathan K. Evanson
This study investigates the effects of Salubrinal and ISRIB on eIF2 phosphorylation in TBI-induced traumatic optic neuropathy, finding that both drugs impair visual function in control animals and show limited benefit in injured mice.
bioRxiv · Feb 15, 2024 · PreprintNeuroscience