Shelby M. Hetzer

A human pluripotent stem cell tri-culture platform to elucidate microglial regulation of retinal ganglion cells in neuroinflammation

This study uses a human pluripotent stem cell tri-culture system to investigate how microglia influence retinal ganglion cell health and disease in neuroinflammation.

Delayed protective effect of chronic variable stress on optic tract axonal degeneration after experimental TBI

This study shows that chronic variable stress after TBI initially worsens axonal degeneration but later provides a delayed protective effect, possibly through changes in microglial and astrocytic phagocytic activity.

Autophagy Disruption Reduces mTORC1 Activation Leading to Retinal Ganglion Cell Neurodegeneration Associated with Glaucoma

This study shows that autophagy disruption reduces mTORC1 activation, leading to retinal ganglion cell degeneration in glaucoma, and identifies potential therapeutic targets.

Targeting eIF2α in TBI-induced traumatic optic neuropathy: Effects of Salubrinal and the Integrated Stress Response Inhibitor.

This study investigates the effects of Salubrinal and ISRIB on eIF2 phosphorylation in TBI-induced traumatic optic neuropathy, finding that both drugs impair visual function in control animals and show limited benefit in injured mice.

Model matters: Differential outcomes in traumatic optic neuropathy pathophysiology between blunt and blast-wave mediated head injuries.

This study compares blunt and blast-wave mediated head injuries in mice, finding distinct visual system injury patterns and histological outcomes.

Brief oxygen exposure after traumatic brain injury speeds recovery and promotes adaptive chronic endoplasmic reticulum stress responses.

This study shows that brief oxygen exposure after traumatic brain injury in adolescents reduces mortality, improves visual function, and alters endoplasmic reticulum stress responses.

Indirect traumatic optic neuropathy after head trauma in adolescent male mice is associated with behavioral visual impairment, neurodegeneration, and elevated endoplasmic reticulum stress markers at acute and subacute times.

This study investigates visual impairment and neurodegeneration in adolescent mice after head trauma, showing retinal ganglion cell injury, axonal degeneration, and elevated ER stress markers.

Greater neurodegeneration and behavioral deficits after single closed head traumatic brain injury in adolescent vs adult mice

This study compares the effects of traumatic brain injury in adolescent and adult mice, finding greater neurodegeneration, mortality, and memory deficits in adolescents.