Enhanced food motivation in obese mice is controlled by D1R expressing spiny projection neurons in the nucleus accumbens.
Bridget A. Matikainen‐Ankney, Alex A. Legaria, Yvan M. Vachez, Caitlin A. Murphy, Yiyan Pan, Robert F Schaefer, Quinlan McGrath, Justin G. Wang, Maya N Bluitt, Aaron J. Norris, Meaghan C. Creed, Alexxai V. Kravitz
This study shows that obese mice exhibit increased activity in D1R-expressing spiny projection neurons in the nucleus accumbens during food seeking, which enhances food motivation and contributes to diet-induced obesity.
bioRxiv · Jan 12, 2022 · PreprintNeuroscience