Author

Robert K. Semple

Primary ORCID profile (0000-0001-6539-3069 · 8 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Robert K. SempleiD8 papers · Institute of Genetics and Cancer

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Bart Vanhaesebroeck· 1 shared Franziska VöllmyiD· 1 shared James LongdeniD· 1 shared Kenneth G. Macleod· 1 shared Larissa S. Moniz· 1 shared Neil O. Carragher· 1 shared Rachel G. Knox· 1 shared Ralitsa R. Madsen· 1 shared

Activity by Year

2020-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Bart Vanhaesebroeck

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1 paper

Recent·Most cited

NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CAH1047R homozygosity in pluripotent stem cells

Ralitsa R. Madsen, James Longden, Rachel G. Knox, Xavier Robin, Franziska Völlmy, Kenneth G. Macleod, Larissa S. Moniz, Neil O. Carragher, Rune Linding, Bart Vanhaesebroeck, Robert K. Semple

This study shows that PIK3CAH1047R homozygosity in hPSCs leads to self-sustained stemness via enhanced NODAL/TGFβ signalling, which can be reversed by TGFβ inhibition.

bioRxiv · Jul 9, 2020Cancer Biology