Author

Xavier Robin

SIB Swiss Institute of BioinformaticsORCID 0000-0002-6813-3200Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Franziska VöllmyiD· 2 shared James LongdeniD· 2 shared Rune LindingiD· 2 shared Bart Vanhaesebroeck· 1 shared Clemens IsertiD· 1 shared Conor J HowardiD· 1 shared Craig D. SimpsoniD· 1 shared Daniel KovtuniD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Franziska VöllmyORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

PLINDER: The protein-ligand interactions dataset and evaluation resource

Janani Durairaj, Yusuf O. Adeshina, Zhonglin Cao, Xuejin Zhang, Vladimiras Oleinikovas, Thomas J. Duignan, Zachary D. McClure, Xavier Robin, Gabriel Studer, Daniel Kovtun, Emanuele Rossi, Guoqing Zhou, Srimukh Prasad Veccham, Clemens Isert, Yuxing Peng, , Luca Naef

PLINDER provides a large, annotated PLI dataset with diverse annotations and improved evaluation splits to better assess computational methods for drug design.

bioRxiv · Jul 17, 2024 · PreprintBiochemistry

NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CAH1047R homozygosity in pluripotent stem cells

Ralitsa R. Madsen, James Longden, Rachel G. Knox, Xavier Robin, Franziska Völlmy, Kenneth G. Macleod, Larissa S. Moniz, Neil O. Carragher, Rune Linding, Bart Vanhaesebroeck, Robert K. Semple

This study shows that PIK3CAH1047R homozygosity in hPSCs leads to self-sustained stemness via enhanced NODAL/TGFβ signalling, which can be reversed by TGFβ inhibition.

bioRxiv · Jul 9, 2020Cancer Biology

Probability-based detection of phosphoproteomic uncertainty reveals rare signaling events driven by oncogenic kinase gene fusion

Xavier Robin, Franziska Völlmy, Jesper Ferkinghoff‐Borg, Conor J Howard, Tom Altenburg, Mathias Engel, Craig D. Simpson, Gaye Saginc, Simon Koplev, Edda Klipp, James Longden, Rune Linding

The paper introduces a Bayesian method to estimate protein concentrations and phosphorylation site occupancy ratios from mass spectrometry data, applied to study PRKAR1A-RET gene fusion effects.

bioRxiv · Apr 29, 2019 · PreprintSystems Biology