Rune Linding

This paper introduces a Thermodynamically Explicit kinetic framework for dynamic metabolic modeling, validated on glycolysis, offering a scalable tool for genome-wide applications.

Positional scanning peptide arrays profile substrate sequence specificities across 303 human serine/threonine kinases, enabling computational kinase-substrate annotation and signaling pathway inference across the human phosphoproteome.

This study shows that PIK3CAH1047R homozygosity in hPSCs leads to self-sustained stemness via enhanced NODAL/TGFβ signalling, which can be reversed by TGFβ inhibition.

The paper introduces a Bayesian method to estimate protein concentrations and phosphorylation site occupancy ratios from mass spectrometry data, applied to study PRKAR1A-RET gene fusion effects.