Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies.
Sebastian Scott Oakley, Karen E. Marshall, Georg Meisl, Alice C. Copsey, Mahmoud Bukar Maina, Robert Milton, Thomas Vorley, John M. D. Storey, Charles R. Harrington, Claude M. Wischik, Wei‐Feng Xue, Louise C. Serpell
This study investigates how inhibiting disulphide bonding in truncated tau affects its self-assembly into seed-competent structures, revealing enhanced aggregation rates and implications for tauopathy research.
bioRxiv · Feb 5, 2025 · PreprintBiochemistry