Wei‐Feng Xue

Structural evolution of a yeast amyloid in vivo is shaped by chaperones

This study shows that chaperones shape the structural evolution of yeast prion amyloids during maturation, with Hsp104 inhibiting structural diversity.

Three-dimensional single-particle reconstruction by atomic force microscopy allows rapid structural-based validation of recombinant SARS-CoV-2 Spike protein from a single topology image

This paper develops a method to perform three-dimensional single-particle reconstruction using AFM for rapid structural validation of proteins, demonstrated on SARS-CoV-2 Spike protein.

Engineered yeast biofilms deliver plastic degrading enzymes to PET substrates

This paper develops engineered yeast biofilms that deliver PET-degrading enzymes directly to substrates, demonstrating a proof-of-principle for biofilm-based bioremediation without enzyme purification.

The architecture of amyloid fibrils formed by a human tau-derived hexapeptide VQIVYK

This paper investigates the structure of amyloid fibrils formed by the human tau-derived hexapeptide VQIVYK, revealing a polymorphous population with a twisted protofilament architecture.

Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies.

This study investigates how inhibiting disulphide bonding in truncated tau affects its self-assembly into seed-competent structures, revealing enhanced aggregation rates and implications for tauopathy research.

Heterotypic Aβ interactions facilitate amyloid assembly and modify amyloid structure

This study shows heterotypic interactions between Aβ APRs and homologous protein segments accelerate Aβ assembly, alter fibril morphology, and are enriched in AD plaques but not in mouse models.