The role of aneuploidy and polyclonality in the adaptation of the Protozoan parasite Leishmania to high drug pressure
Gabriel H. Negreira, Robin de Groote, Dorien Van Giel, Pieter Monsieurs, Ilse Maes, Géraldine De Muylder, Frederik Van den Broeck, Jean‐Claude Dujardin, Malgorzata A. Domagalska
This study investigates how aneuploidy and polyclonality contribute to Leishmania's adaptation to high drug pressure, showing different dynamics depending on the drug and pre-existing mutations.
bioRxiv · Dec 22, 2022 · PreprintMolecular Biology