Pieter Monsieurs

This study shows that Trypanosoma congolense expresses multiple Variant Surface Glycoprotein genes in single cells, unlike Trypanosoma brucei, which uses monoallelic transcription.

The paper identifies persister-like cells in Leishmania that survive antimony treatment and show cross-tolerance to other drugs.

This study maps DNA replication origins in Trypanosoma brucei using stranded short nascent strand sequencing, revealing their sequence, structural, and chromatin features.

The paper presents a transcriptome time-course of Plasmodium knowlesi A1-H.1 during its intraerythrocytic developmental cycle, identifies stage-specific biomarkers, and develops a webtool for comparative analysis with Plasmodium vivax.

This paper introduces a high-throughput single-cell DNA sequencing method for Leishmania, revealing genomic heterogeneity through structural and nucleotide analysis.

This paper develops a novel single-cell RNA sequencing technology for Plasmodium natural infections, enabling field studies in low-resource settings by validating sample preparation methods and generating a comprehensive dataset.

The paper sequences Leishmania tropica genomes from human skin samples in Ethiopia, identifying a new drug-resistant variant and suggesting an outbreak.

This study investigates how aneuploidy and polyclonality contribute to Leishmania's adaptation to high drug pressure, showing different dynamics depending on the drug and pre-existing mutations.

The paper uses high throughput single-cell genome sequencing to study mosaic aneuploidy in Leishmania donovani, finding rapid karyotype changes and chromosome-specific adaptations.

This paper uses high-throughput single-cell genome sequencing to analyze karyotype variation in a clonal Leishmania donovani population, revealing mosaic aneuploidy and its potential adaptive role.