Malgorzata A. Domagalska

The paper identifies persister-like cells in Leishmania that survive antimony treatment and show cross-tolerance to other drugs.

This paper introduces a high-throughput single-cell DNA sequencing method for Leishmania, revealing genomic heterogeneity through structural and nucleotide analysis.

The paper sequences Leishmania tropica genomes from human skin samples in Ethiopia, identifying a new drug-resistant variant and suggesting an outbreak.

This study analyzes the genome diversity of Leishmania aethiopica, identifying interspecific hybrids and revealing genetic diversity and recombination patterns.

This study investigates how aneuploidy and polyclonality contribute to Leishmania's adaptation to high drug pressure, showing different dynamics depending on the drug and pre-existing mutations.

This study uses multi-omics analysis to show that aneuploidy in Leishmania causes proportional changes in transcript and protein abundance, with post-transcriptional regulation compensating for some effects.

The paper quantifies transcriptome and metabolome changes in Leishmania during quiescence induced by drug pressure or stationary phase, revealing global transcriptional reduction and specific upregulation of membrane and autophagy-related genes.

The paper shows genome instability in Leishmania enables fitness gain through epistatic gene copy number variations and compensatory post-transcriptional mechanisms.

The paper uses high throughput single-cell genome sequencing to study mosaic aneuploidy in Leishmania donovani, finding rapid karyotype changes and chromosome-specific adaptations.

The paper shows Leishmania donovani lacks detectable DNA methylation, enabling enrichment of parasite DNA from mixed samples using methyl-binding columns.

This paper uses high-throughput single-cell genome sequencing to analyze karyotype variation in a clonal Leishmania donovani population, revealing mosaic aneuploidy and its potential adaptive role.