A novel inhibitor against the bromodomain PfBDP1 of the malaria pathogen Plasmodium falciparum
Marius Amann, Robin Warstat, Kay Kristin Rechten, Philip Theuer, Magdalena Schustereder, Sophie Clavey, Bernhard Breit, Oliver Einsle, Martin J. Hügle, Michaela Petter, Stefan Günther
This study identifies a potent inhibitor of PfBDP1 in Plasmodium falciparum through virtual docking, calorimetry, and crystallography, showing parasite sensitivity and potential as a malaria therapeutic.
ChemMedChem · Mar 18, 2025Peer-reviewedBiochemistry