Oliver Einsle

This study investigates how metabolic signals regulate glutamine synthetase AMPylation in Herbaspirillum seropedicae and reveals the structural mechanism of enzyme inhibition by AMPylation.

This paper reports cryo-EM structures of EMO and EMO-ETF complex from Syntrophus aciditrophicus, revealing a twin-heme-mediated reverse redox-loop mechanism for methanogenesis from fatty acids.

This study uses computational methods to stabilize Plasmodium falciparum proteins, enabling reliable biophysical analysis and drug discovery.

This study identifies a potent inhibitor of PfBDP1 in Plasmodium falciparum through virtual docking, calorimetry, and crystallography, showing parasite sensitivity and potential as a malaria therapeutic.

This study characterizes two PPK2 enzymes, showing their broad substrate specificity and ability to selectively synthesize pyrimidine nucleoside diphosphates with high yield.

The paper reconstructs the structural evolution of nitrogenase enzymes over 3 billion years using phylogenetics, ancestral sequence reconstruction, crystallography, and deep learning.