Accelerated trans-sulfuration metabolically defines a discrete subclass of ALS patients
Qiuying Chen, Davinder K. Sandhu, Csaba Konràd, Dipa Roychoudhury, Benjamin I. Schwartz, Roger R. Cheng, Kirsten G. Bredvik, Hibiki Kawamata, Elizabeth L. Calder, Lorenz Studer, Steven M. Fischer, Giovanni Manfredi, Steven S. Gross
The paper identifies a subclass of sporadic ALS patients with metabolic defects in trans-sulfuration, characterized by increased cysteine and glutathione synthesis and distinct metabolic responses.
bioRxiv · Apr 16, 2019 · PreprintNeuroscience