The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration
Amanda Engstrom, Alicia C. Walker, Rohitha A. Moudgal, Dexter A. Myrick, Stephanie M. Kyle, Yu Bai, M. Jordan Rowley, David J. Katz
This study shows that pathological tau sequesters LSD1, leading to neurodegeneration, and that modulating LSD1 can mitigate tau-induced damage in a mouse model.
Proceedings of the National Academy of Sciences · Nov 2, 2020Peer-reviewedNeuroscience