Author

Alicia C. Walker

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Neuroscience· 2 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alec J. WalkeriD· 2 shared Beth StevensiD· 2 shared Lasse Dissing‐Olesen· 2 shared Samuel E. MarshiD· 2 shared Yvanka de SoysaiD· 2 shared Abdulraouf AbdulraoufiD· 1 shared Adam M. H. Young· 1 shared Amanda EngstromiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

Alec J. WalkerORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Early-life stromal niches orchestrate B lymphopoiesis at the brain's borders

Alec J. Walker, Theodore M. Fisher, Sydney K. Caldwell, Anushree S. Gupte, Justin M. Reimertz, Bristy Sabikunnahar, Samuel E. Marsh, Yvanka de Soysa, Vahid Gazestani, Alicia C. Walker, Youtong Huang, Ananya Mavinkurve, Helena J. Barr, Toby Black Lanser, Sarah R. Murphy, , Beth Stevens

This study identifies the murine dura mater as a transient niche for early-postnatal B lymphopoiesis, highlighting the role of CXCL12-expressing fibroblasts in supporting B cell development.

bioRxiv · Nov 27, 2025 · PreprintImmunology

Single Cell Sequencing Reveals Glial Specific Responses to Tissue Processing & Enzymatic Dissociation in Mice and Humans

Samuel E. Marsh, Alec J. Walker, Tushar Kamath, Lasse Dissing‐Olesen, Timothy R. Hammond, Yvanka de Soysa, Adam M. H. Young, Sarah Murphy, Abdulraouf Abdulraouf, Naeem M. Nadaf, Connor Dufort, Alicia C. Walker, Liliana E. Lucca, Velina Kozareva, Charles R. Vanderburg, , Beth Stevens

The paper shows enzymatic dissociation causes gene expression changes in microglia and proposes a protocol to reduce these artifacts in scRNA-seq.

Nature Neuroscience · Mar 1, 2022Peer-reviewedNeuroscience

The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration

Amanda Engstrom, Alicia C. Walker, Rohitha A. Moudgal, Dexter A. Myrick, Stephanie M. Kyle, Yu Bai, M. Jordan Rowley, David J. Katz

This study shows that pathological tau sequesters LSD1, leading to neurodegeneration, and that modulating LSD1 can mitigate tau-induced damage in a mouse model.

Proceedings of the National Academy of Sciences · Nov 2, 2020Peer-reviewedNeuroscience