Obesity induces phenotypic switching of gastric smooth muscle cells through the activation of the PPARD/PDK4/ANGPTL4 pathway
Sanaa Dekkar, Kamilia Mahloul, Amandine Falco, Karidia Konate, Romane Pisteur, Sarah Maurel, Laurent Maı̈moun, Norbert Chauvet, Prisca Boisguérin, David Nocca, Ariane Sultan, Florian Pallot, Guillaume Walther, Nicolas Cénac, Cyril Breuker, , Pascal de Santa Barbara
This study identifies the PPARD/PDK4/ANGPTL4 pathway as a mechanism by which obesity induces phenotypic switching of gastric smooth muscle cells, leading to dysmotility.
Journal of Biomedical Science · Jul 12, 2025Peer-reviewedPhysiology