Prisca Boisguérin

Sequence engineering at non-motif modulator residues yields a peptide that effectively targets a single PDZ protein in a disease-relevant cellular context

The paper engineers a peptide that selectively targets a single PDZ domain in a cystic fibrosis model, enhancing chloride efflux.

Breaking the redundancy: TAZ outperforms YAP1 in GIST progression

This study shows that TAZ, not YAP1, is more critical for GIST progression and that targeting TAZ could be a better therapeutic strategy.

Obesity induces phenotypic switching of gastric smooth muscle cells through the activation of the PPARD/PDK4/ANGPTL4 pathway

This study identifies the PPARD/PDK4/ANGPTL4 pathway as a mechanism by which obesity induces phenotypic switching of gastric smooth muscle cells, leading to dysmotility.

Multi-protein silencing using WRAP-based nanoparticles: a proof of concept

This study demonstrates that WRAP5 nanoparticles delivering multiple siRNAs can silence multiple target proteins and reduce proliferation in glioblastoma and GIST cells.