The complement system supports normal postnatal development and gonadal function in both sexes
Arthur S. Lee, Jannette Rusch, Abul Usmani, Ana C. Lima, Wendy S.W. Wong, Ni Huang, Maarja Lepamets, Katinka A. Vigh‐Conrad, Ronald E. Worthington, Reedik Mägi, John E. Niederhuber, Xiaobo Wu, John P. Atkinson, Rex A. Hess, Donald F. Conrad
The paper identifies CSMD1 variants linked to gonadal function in both sexes and shows that Csmd1 knockout mice have reproductive defects, implicating the complement system in postnatal development.
bioRxiv · Dec 14, 2017 · PreprintDevelopmental Biology