Author

Xiaobo Wu

Washington University in St. LouisORCID 0000-0002-6703-2272Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Developmental Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

John P. AtkinsoniD· 3 shared Hrishikesh S. KulkarniiD· 2 shared Lorena GarnicaiD· 2 shared Aasritha NallapuiD· 1 shared Aayusha ThapaiD· 1 shared Abul UsmaniiD· 1 shared Alberto LopeziD· 1 shared Alexander EarhartiD· 1 shared

Activity by Year

2017-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersPhysiology

John P. AtkinsonORCID

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Author profile →

4 papers

Recent·Most cited

The C3-C3aR axis modulates trained immunity in alveolar macrophages

Alexander Earhart, Alberto Lopez, Josue I. Hernandez, Aasritha Nallapu, Deebly Chavez, Sayahi Suthakaran, Brian Yang, Jungheun Hyun, Rafael Aponte Alburquerque, Marick Starick, Lorena Garnica, Ayşe Naz Ozantürk, Rahul Kumar Maurya, Xiaobo Wu, Jeffrey A. Haspel, , Hrishikesh S. Kulkarni

This study shows that C3 modulates trained immunity in alveolar macrophages via C3aR signaling, enhancing glycolytic activity and cytokine output.

eLife · Aug 18, 2026Peer-reviewedImmunology

Adipose-driven complement-lipid reprogramming controls nociceptive vulnerability in obesity-associated osteoarthritis

Hope D. Welhaven, Joseph B. Lesnak, Kristin L. Lenz, Bethany A. Andoko, Arin K. Oestreich, Ashley N. Plumb, Katelyn E. Sadler, Luke E. Springer, Jacob G. Brockert, Darren Dumlao, Antonina M. Akk, Xiaobo Wu, Huimin Yan, Bo Zhang, Stephen P. Messier, , Kelsey H. Collins

The paper identifies an adipose-complement-lipid axis that systemically regulates sensory neuron sensitization, explaining pain-structure discordance in obesity-associated osteoarthritis.

bioRxiv · Mar 21, 2026 · PreprintPhysiology

Impaired complement regulation drives chronic lung allograft dysfunction after lung transplantation.

Hrishikesh S. Kulkarni, Laneshia K. Tague, Daniel R. Calabrese, Fuyi Liao, Zhiyi Liu, Lorena Garnica, Nishanth R Shankar, Xiaobo Wu, Devesha Hrishikesh Kulkarni, Aayusha Thapa, Dequan Zhou, Yan Tao, Victoria E. Davis, Cory T. Bernadt, Derek E. Byers, , Andrew E. Gelman

This study identifies a genetic variant linked to impaired complement regulation that worsens chronic lung allograft dysfunction-free survival by promoting B cell activation and donor-specific antibodies.

Journal of Clinical Investigation · Nov 11, 2025Peer-reviewedImmunology

The complement system supports normal postnatal development and gonadal function in both sexes

Arthur S. Lee, Jannette Rusch, Abul Usmani, Ana C. Lima, Wendy S.W. Wong, Ni Huang, Maarja Lepamets, Katinka A. Vigh‐Conrad, Ronald E. Worthington, Reedik Mägi, John E. Niederhuber, Xiaobo Wu, John P. Atkinson, Rex A. Hess, Donald F. Conrad

The paper identifies CSMD1 variants linked to gonadal function in both sexes and shows that Csmd1 knockout mice have reproductive defects, implicating the complement system in postnatal development.

bioRxiv · Dec 14, 2017 · PreprintDevelopmental Biology