Wendy S.W. Wong

This study analyzes breast cancer GWAS across multiple ancestries, finding similar heritability and genetic correlations, and identifies shared regulatory and cellular contexts.

The paper identifies subgroups of preterm birth patients with shared protein interaction networks and pathway enrichments using sequencing and bioinformatic analysis.

The paper investigates family-specific contributions to de novo mutations and finds that stochasticity explains most of the variation.

The paper decomposes mutation rate and spectra variation in human germline using blind source separation, identifying nine processes including those related to DNA damage and replication timing.

The paper identifies maternal age-related mutation clusters in germline de novo mutations linked to double-strand break processes.

The paper analyzes Mendelian inheritance errors in whole genome sequenced trios, finding they are enriched in repeats and cluster in copy number loss regions, providing population-specific profiles for quality control.

The paper identifies CSMD1 variants linked to gonadal function in both sexes and shows that Csmd1 knockout mice have reproductive defects, implicating the complement system in postnatal development.