Jannette Rusch

The paper shows that the nuclear fragment of fat cadherin, generated by cleavage, regulates gene expression by interacting with Hippo pathway components and other factors.

The paper develops a framework to analyze single-cell transcriptomes from mouse testes, identifying gene regulatory programs and pathological processes in mutant strains.

The paper identifies CSMD1 variants linked to gonadal function in both sexes and shows that Csmd1 knockout mice have reproductive defects, implicating the complement system in postnatal development.