BiophysicsVirusesPeer-reviewed
Elucidating the molecular determinants for binding modes of a third-generation HIV-1 integrase strand transfer inhibitor: Importance of side chain and solvent reorganization
Qinfang Sun, Avik Biswas, Dmitry Lyumkis…·Nanjie Deng
This study identifies molecular determinants of binding modes for a third-generation HIV-1 integrase inhibitor, showing that side chain and solvent reorganization, along with conformational entropy, influence ligand binding preferences in closely related viral intasomes.
6 citations