Author

Rory Deignan

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Systems Biology· 1

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Organism:human· 1 Approach:statistical model· 1

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Dawn WalkeriD· 1 shared Fabio DercoleiD· 1 shared Kenneth Y. WertheimiD· 1 shared Matteo ItaliaiD· 1 shared Melody J ParkeriD· 1 shared

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Dawn WalkerORCID

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1 paper

Recent·Most cited

A Novel Prognostic Metric Resolves the MYCN enigma in Silico and Points to a Biosynthetic Regulatory Shift Driven by MYCN Amplification in Neuroblastoma

Matteo Italia, Melody J Parker, Rory Deignan, Fabio Dercole, Dawn Walker, Kenneth Y. Wertheim

This paper introduces a prognostic metric, p53/MYCN, to explain the non-monotonic relationship between MYCN expression and clinical outcomes in neuroblastoma through computational modeling and simulations.

bioRxiv · Nov 13, 2025 · PreprintSystems Biology