Kenneth Y. Wertheim

A Novel Prognostic Metric Resolves the MYCN enigma in Silico and Points to a Biosynthetic Regulatory Shift Driven by MYCN Amplification in Neuroblastoma

This paper introduces a prognostic metric, p53/MYCN, to explain the non-monotonic relationship between MYCN expression and clinical outcomes in neuroblastoma through computational modeling and simulations.

Multi-Approach and Multi-Scale Model of CD4+ T Cells Predicts Switch-Like and Oscillatory Emergent Behaviors in Inflammatory Response to Infection

The paper develops a multi-scale model of CD4+ T cells integrating multiple modeling approaches to predict switch-like and oscillatory behaviors in inflammatory responses.