Author

Dawn Walker

InsigneoORCID 0000-0001-8801-8093Unclaimed ORCID profile · follow to get notified of new preprints

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Systems Biology· 1

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Organism:human· 1 Approach:statistical model· 1

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Fabio DercoleiD· 1 shared Kenneth Y. WertheimiD· 1 shared Matteo ItaliaiD· 1 shared Melody J ParkeriD· 1 shared Rory Deignan· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperSystems Biology

Fabio DercoleORCID

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1 paper

Recent·Most cited

Systems BiologybioRxivPreprintNov 13, 2025

A Novel Prognostic Metric Resolves the MYCN enigma in Silico and Points to a Biosynthetic Regulatory Shift Driven by MYCN Amplification in Neuroblastoma

Matteo Italia, Melody J Parker, Rory Deignan…·Kenneth Y. Wertheim

This paper introduces a prognostic metric, p53/MYCN, to explain the non-monotonic relationship between MYCN expression and clinical outcomes in neuroblastoma through computational modeling and simulations.

DOI 10.1101/2025.11.13.688307

humanstatistical model

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