Generation and validation of a CRF1:Cre transgenic rat: The role of central amygdala CRF1 in nociception and anxiety-like behavior
Marcus M. Weera, Abigail E. Agoglia, Eliza A. Douglass, Zhiying Jiang, Shivakumar Rajamanickam, Rosetta S. Shackett, Melissa A. Herman, Nicholas J. Justice, Nicholas W. Gilpin
The paper generates and validates a CRF1:Cre transgenic rat to study the role of CRF1-expressing neurons in anxiety and nociception, finding that activation of these cells increases anxiety-like behavior and pain responses.
eLife · Apr 7, 2022Peer-reviewedNeuroscience