Zhiying Jiang

The paper identifies a hypothalamic inhibitory circuit that modulates stress response scalability by regulating GABA release in response to prolonged stressors.

This study shows glucocorticoids rapidly desensitize CRH neurons to norepinephrine by regulating α1 adrenoreceptor trafficking through nitrosylation and endocytosis.

The paper identifies a glutamatergic circuit from the basal forebrain to the ventral tegmental area that reduces appetite and causes anorexia-like behaviors by decreasing dopamine release in the nucleus accumbens.

The paper generates and validates a CRF1:Cre transgenic rat to study the role of CRF1-expressing neurons in anxiety and nociception, finding that activation of these cells increases anxiety-like behavior and pain responses.

The paper shows that acute stress reduces the response of CRH neurons to norepinephrine and physiological stress through glucocorticoid-mediated adrenoreceptor desensitization.

The paper reveals a novel retrograde signaling mechanism in CRF neurons where astrocytes amplify dendritic volume transmission by responding to norepinephrine-induced ATP release.