Characterization of DNA methylation in PBMCs and donor-matched iPSCs shows methylation is reset during stem cell reprogramming
Xylena Reed, Cory A. Weller, Sara Sáez-Atiénzar, Alexandra G. Beilina, Sultana Solaiman, Makayla K. Portley, Mary Kaileh, Roshni Roy, Jinhui Ding, Ann Zenobia Moore, D. Thad Whitaker, Bryan J. Traynor, Jesse Raphael Gibbs, Sonja W. Scholz, Mark Cookson
The paper shows that DNA methylation is reset in iPSCs compared to donor PBMCs, with unique methylation sites influenced by genetics in each cell type.
bioRxiv · Dec 13, 2024 · PreprintMolecular Biology