Hepatic cellular stress response pathways exhibit species differences in basal and inducible activity
Hannah Coghlan, Sophie Regan, Bhavik Chouhan, Dominic P. Williams, Rowena Sison-Young, Andrew R. Jones, Ian M. Copple
This study compares hepatic stress response pathways in humans and preclinical animal species, finding rodents have greater basal and adaptive capacity for mitigating chemical insults.
Toxicological Sciences · May 27, 2026Peer-reviewedPharmacology & Toxicology