Dominic P. Williams

Hepatic cellular stress response pathways exhibit species differences in basal and inducible activity

This study compares hepatic stress response pathways in humans and preclinical animal species, finding rodents have greater basal and adaptive capacity for mitigating chemical insults.

Improved Detection of Drug-Induced Liver Injury by Integrating Predicted in vivo and in vitro Data

This paper develops a machine learning model to predict drug-induced liver injury by integrating in vitro and in vivo data with chemical features, achieving improved detection and human-specific sensitivity.