Vcam1 in endothelial and stromal cells regulates hematopoietic stem cell contact with the niche
Octavia Santis, Alice Alhaj Kadour, Sobhika Agarwala, Wantong Li, Bradley Wayne Blaser, Michael R. Lasarev, Roxana A. Alexandridis, Anthony J. Veltri, Khaliun Enkhbayar, Elliott J. Hagedorn, Owen J. Tamplin
The paper identifies Vcam1-expressing endothelial and stromal cells as critical for HSPC retention in the zebrafish CHT niche through Itga4-Vcam1 interactions.
bioRxiv · Aug 30, 2025 · PreprintDevelopmental Biology