Owen J. Tamplin

This study identifies GABA as a regulator of HSPCs produced by B cells and endothelial cells in the bone marrow, showing lower GABA levels reduce proliferation and increase B cell differentiation.

The paper identifies Vcam1-expressing endothelial and stromal cells as critical for HSPC retention in the zebrafish CHT niche through Itga4-Vcam1 interactions.

The paper tracks single HSPCs in zebrafish using light and electron microscopy to identify a new niche cell type and resolve their ultrastructural interactions.