Author

Elliott J. Hagedorn

Boston UniversityORCID 0000-0002-3824-3249Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:zebrafish· 4 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Khaliun EnkhbayariD· 3 shared Leonard Ira ZoniD· 3 shared Brian LiiD· 2 shared Ji Wook KimiD· 2 shared Raquel Riquelme· 2 shared Samuel J. WattrusiD· 2 shared Alexander van OudenaardeniD· 1 shared Alice Alhaj Kadour· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersDevelopmental Biology

Khaliun EnkhbayarORCID

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Author profile →

5 papers

Recent·Most cited

The endothelial scavenger receptor stab2 is required for proper hematopoietic stem and progenitor cell development in the fetal blood stem cell niche

Gwendolyn M. Beacham, Zewde Ingram, Reema A Elrefaie, Khaliun Enkhbayar, Zachary R Zener, Leila Affini, Zainab N Wasim, Maura C Dodge, Sandeep Sreerama, María de los Ángeles Serrano, Elliott J. Hagedorn

This study shows that stab2 is essential for fetal HSPC development in the niche, with loss of stab2 reducing HSPC numbers and altering sub-population balances.

bioRxiv · Jul 23, 2026 · PreprintDevelopmental Biology

Vcam1 in endothelial and stromal cells regulates hematopoietic stem cell contact with the niche

Octavia Santis, Alice Alhaj Kadour, Sobhika Agarwala, Wantong Li, Bradley Wayne Blaser, Michael R. Lasarev, Roxana A. Alexandridis, Anthony J. Veltri, Khaliun Enkhbayar, Elliott J. Hagedorn, Owen J. Tamplin

The paper identifies Vcam1-expressing endothelial and stromal cells as critical for HSPC retention in the zebrafish CHT niche through Itga4-Vcam1 interactions.

bioRxiv · Aug 30, 2025 · PreprintDevelopmental Biology

Transcription factor induction of vascular blood stem cell niches in vivo

Elliott J. Hagedorn, Julie R. Perlin, Rebecca J. Freeman, Samuel J. Wattrus, Tianxiao Han, Clara Mao, Ji Wook Kim, Inés Fernández-Maestre, Madeleine L. Daily, Christopher R. D'Amato, Michael J. Fairchild, Raquel Riquelme, Brian Li, Dana A.V.E. Ragoonanan, Khaliun Enkhbayar, , Leonard Ira Zon

This study identifies transcription factors that induce vascular blood stem cell niches in vivo, enabling synthetic niche generation and potential therapeutic applications.

Developmental Cell · Apr 28, 2023Peer-reviewedDevelopmental Biology

Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality

Samuel J. Wattrus, Mackenzie L. Smith, Cecília Pessoa Rodrigues, Elliott J. Hagedorn, Ji Wook Kim, Bogdan Budnik, Leonard Ira Zon

The paper shows that macrophages interact with nascent blood stem cells in zebrafish embryos, influencing their survival and clonality through mechanisms involving calreticulin.

Science · Sep 22, 2022Peer-reviewedDevelopmental Biology

Generation of Mouse-Zebrafish Hematopoietic Tissue Chimeric Embryos for Hematopoiesis and Host-Pathogen Interaction Studies

Margarita Parada-Kusz, Anne E. Clatworthy, Elliott J. Hagedorn, Cristina Peñaranda, Anil V. Nair, Jonathan E. Henninger, Christoph M. Ernst, Brian Li, Raquel Riquelme, Humberto B. Jijon, Eduardo J. Villablanca, Leonard Ira Zon, Deborah Tan Hung, Miguel L. Allende

This study xenografts murine bone marrow cells into zebrafish embryos to study hematopoiesis and host-pathogen interactions, showing successful integration and immune response.

Disease Models & Mechanisms · Sep 28, 2018Peer-reviewedDevelopmental Biology