Expression of the human immunomodulatory protein, human B7-1 (CD80), accelerates neuroinflammation, synaptic loss, microvascular instability and lethality in a murine model of Alzheimers Disease
Víctor Danelon, Sarah C. Garrett-Thomson, Nicholas C. Morano, Ruben Constanza, Pouneh Kermani, Roshelle S. Smith, Steven C. Almo, Francis S. Lee, Barbara L. Hempstead
This study shows that expressing human B7-1 in mice accelerates AD-like symptoms by enhancing neuroinflammation and synaptic loss.
bioRxiv · Feb 5, 2026 · PreprintNeuroscience