Francis S. Lee

Microglial sTREM2 limits dyskinesia and acts on TrkB to support circuit plasticity

The paper identifies a microglial gene program linked to dyskinesia in Parkinson's disease and shows that sTREM2 reduces dyskinesia by modulating TrkB signaling and synaptic plasticity.

Expression of the human immunomodulatory protein, human B7-1 (CD80), accelerates neuroinflammation, synaptic loss, microvascular instability and lethality in a murine model of Alzheimers Disease

This study shows that expressing human B7-1 in mice accelerates AD-like symptoms by enhancing neuroinflammation and synaptic loss.

Nitrous oxide modulates cortical activity, wake-sleep oscillations, and produces antidepressant-like effects in mice

This study shows that nitrous oxide increases cortical activity, alters wake-sleep oscillations, and produces antidepressant-like effects in mice, similar to ketamine.

Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia

This study shows that increasing 2-AG levels reduces opioid reward but not analgesia in mice, suggesting a potential therapeutic strategy for pain treatment.

Molecular and functional alterations in the cerebral microvasculature in an optimized mouse model of sepsis-associated cognitive dysfunction.

This study develops and validates a mouse model of sepsis-induced cognitive dysfunction, identifying molecular and functional changes in the cerebral microvasculature and their association with cognitive impairment.

A Genetic Variant of Fatty Acid Amide Hydrolase (FAAH) Exacerbates Hormone- Mediated Orexigenic Feeding in Mice

This study shows that the FAAH C385A polymorphism exacerbates hormone-mediated feeding in mice under specific environmental conditions, affecting metabolic outcomes.

Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

Exomes of 24,248 schizophrenia cases and 97,322 controls implicate ultra-rare damaging variants in 10 genes, including GRIN2A and GRIA3, with odds ratios of 3 to 50.

Genomic Modules and Intramodular Network Convergency of Susceptibility and Resilience in Multimodeled Stress in Male Mice

The paper identifies convergent genomic modules in stress models of mice, revealing shared biological functions across different stress paradigms.