Crosstalk between the Methyl-Cytosine Dioxygenase TET3 and the Methyl-CpG-binding protein MECP2 Controls Neuronal Maturation
Franziska R. Traube, Gilles Gasparoni, Anna Winkler, Anna S. Geserich, Hugo Sepúlveda, J. Carlos Angel, Xiaojing Yue, Rouhollah Habibey, Victoria Splith, Gülce I. Gökҫe, Grazia Giorgio, Chiara Bernardini, Ruben Sachsse, Constanze Scheel, Marilla Bickerstaff-Westbrook, , Stylianos Michalakis
The paper shows TET3 and MECP2 interact to regulate neuronal maturation, with TET3 critical for functional development and MECP2 inhibiting TET3 activity.
bioRxiv · Oct 29, 2025 · PreprintNeuroscience