Stylianos Michalakis

This study evaluates gene supplementation of MYO7A via dual AAVs and CRISPR/Cas activation of Myo7b in animal models and human retinal organoids to treat Usher syndrome 1B.

This study identifies CCZ1 as a modulator of TPC2 activity and shows its role in regulating melanoma cell migration through interactions with RAB7a.

The paper shows TET3 and MECP2 interact to regulate neuronal maturation, with TET3 critical for functional development and MECP2 inhibiting TET3 activity.

This paper introduces a method to quantitatively assess viral transduction efficiency in living human retinal organoids using 3D imaging and deep learning.

The paper uses CRISPRa to activate IRD-linked genes in PBMCs to detect transcripts for improved genetic diagnosis of inherited retinal dystrophies.

This study shows that human photoreceptor cells transplanted into human retina organoids integrate structurally, forming clusters with cone and rod photoreceptors and host cell contacts.