Hugo Sepúlveda

Crosstalk between the Methyl-Cytosine Dioxygenase TET3 and the Methyl-CpG-binding protein MECP2 Controls Neuronal Maturation

The paper shows TET3 and MECP2 interact to regulate neuronal maturation, with TET3 critical for functional development and MECP2 inhibiting TET3 activity.

Loss of TET function in T regulatory cells yields ex-Treg cells biased toward T follicular helper cells, causingautoimmune diseases through autoantibody production

This study shows that loss of TET function in Treg cells leads to ex-Treg cells that differentiate into Tfh cells, promoting autoantibody production and autoimmune disease.

Distinct interferon response patterns link to increased transposable element expression in leukocytes of systemic lupus erythematosus patients

This study links increased transposable element (TE) expression in SLE patients to IFN responses, showing strong correlations with disease activity and splicing alterations.

OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide

This study shows that OGT inhibits TET activity, preventing DNA demethylation and transposable element expression in heterochromatin.