Interferon-γ Exposure of Human iPSC-derived Neurons Alters Major Histocompatibility Complex I and Synapsin I Protein Expression
Adam Pavlinek, Rugile Matulevicute, Laura Sichlinger, Lucia Dutan Polit, Nikolaos Armeniakos, Anthony Christopher Vernon, Deepak P. Srivastava
This study shows that IFN-γ exposure in human iPSC-derived neurons increases MHCI and C4A expression while decreasing synapsin I protein, suggesting a role in neurodevelopmental disorders.
bioRxiv · Dec 15, 2021 · PreprintNeuroscience