Deepak P. Srivastava

Schizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neurons

This study investigates the role of ZNF804A in human neurodevelopment, finding it regulates excitatory synapse formation through increased local protein translation in developing cortical glutamatergic neurons.

A human neuron-microglia tri-culture platform to study the influence of microglia on developing neuronal networks in vitro

This paper develops a human neuron-microglia tri-culture platform to study cell-cell interactions during cortical development and disease modeling.

Electrophysiological development and functional plasticity in dissociated human cerebral organoids across multiple cell lines

This study examines electrophysiological development and functional plasticity in dissociated human cerebral organoids across multiple cell lines, showing increasing connectivity and plasticity over time.

Assessing the impact of mono- and bi-allelic deletions in NRXN1 on synaptic function

This study compares mono- and bi-allelic NRXN1 mutations in iPSC-derived neurons, showing bi-allelic mutations cause more severe molecular, synaptic, and functional impairments.

Proteomic Analysis Links Truncated Tau to Lysosome Motility, Autophagy and Endo-lysosomal Dysfunction

This study examines how Tau35 protein affects lysosomal function and autophagy, identifying early pathological changes linked to neurotoxicity in tauopathies.

Exploring the functions of JAKMIP1 in neuronal IL-6/STAT3 signaling and its relevance to chromosome 15q-duplication syndrome

This study investigates JAKMIP1's role in neuronal IL-6/STAT3 signaling and its implications for Dup15q syndrome, finding that JAKMIP1 deficiency impairs signaling and neuritogenesis.

Overexpression of α-Synuclein Alters The Nanoscopic Organisation of Presynaptic Proteins

This study shows that overexpressing α-synuclein variants alters presynaptic protein organisation without changing bouton structure, suggesting a disruption of presynaptic function through the MYCBP2-ELKS axis.

Cell-type-specific DNA methylation dynamics in the prenatal and postnatal human cortex

This study identifies cell-type-specific DNA methylation dynamics in the human cortex across development, highlighting prenatal periods as critical for epigenomic plasticity and linking changes to neurodevelopmental disorders.

Properties of Alzheimers disease brain-derived tau aggregates define tau processing by human astrocytes.

This study shows that tau aggregates from Alzheimer's disease brains are taken up and processed by human astrocytes, with differences in handling linked to astrocyte responses and gene expression changes.

Impact of intragenic NRXN1 deletions on early cortical development

This study investigates the impact of NRXN1 intronic deletions on early cortical development using hiPSCs, finding altered isoform expression and dendritic morphology.

Transcriptional and Cellular Response of hiPSC-derived Microglia-Neural Progenitor Co-Cultures Exposed to IL-6

The paper investigates how IL-6 exposure affects hiPSC-derived microglia-neural progenitor co-cultures, finding minimal transcriptional response in NPCs despite MGLs secreting IL-6R.

Estradiol regulates local synthesis of synaptic proteome via sex-specific mechanisms.

This study shows estradiol increases local synaptic protein synthesis in both sexes, but mTOR signaling is sex-specifically required for certain synaptic proteins.

Social memory in female mice is rapidly modulated by 17β-estradiol through ERK and Akt modulation of synapse formation

This study shows that 17β-estradiol modulates social memory and synapse formation in female mice via ERK and Akt pathways, with ERK also mediating synapse elimination.

Acute IL-6 exposure triggers canonical IL-6R signalling in hiPSC microglia, but not neural progenitor cells.

The paper shows that acute IL-6 exposure activates canonical IL-6R signaling in hiPSC-derived microglia but not neural progenitor cells, with implications for neurodevelopmental disorders.

Attenuated transcriptional response to pro-inflammatory cytokines in schizophrenia hiPSC-derived neural progenitor cells

The paper shows that schizophrenia hiPSC-derived NPCs have a reduced transcriptional response to IFN-gamma compared to controls, with implications for synaptic development and mitochondrial genes.

Genetic correlates of phenotypic heterogeneity in autism

This study identifies genetic correlates of phenotypic heterogeneity in autism by analyzing common and de novo variants across core features and co-occurring disabilities.

Interferon-γ Exposure of Human iPSC-derived Neurons Alters Major Histocompatibility Complex I and Synapsin I Protein Expression

This study shows that IFN-γ exposure in human iPSC-derived neurons increases MHCI and C4A expression while decreasing synapsin I protein, suggesting a role in neurodevelopmental disorders.

Nanoscopic Clustering of Neuroligin-3 and Neuroligin-4X Regulates Growth Cone Organization and Size

This study shows that NLGN3/4X clustering at growth cones promotes neuritogenesis and actin organization in immature human neurons, with ASD-associated variants lacking these effects.

Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons.

The paper develops a novel epigenetic clock for fetal brain development to predict prenatal age in iPSCs and derived neurons, showing they remain epigenetically fetal despite differentiation.

Schizophrenia Risk Proteins ZNF804A and NT5C2 Interact at Synapses

This study shows ZNF804A and NT5C2 interact at synapses in cortical neurons, suggesting they function as a complex in schizophrenia risk.

Application of Airy beam Light sheet microscopy to examine early neurodevelopmental structures in 3D hiPSC-derived human cortical spheroids

This paper optimizes Airy-beam light sheet microscopy to image 3D structures in hiPSC-derived human cortical spheroids, enabling high-resolution analysis of neurodevelopmental processes.

Atypical neurogenesis in induced pluripotent stem cell (iPSC) from autistic individuals

This study uses iPSCs from autistic individuals to identify early neurodevelopmental differences during cortical and midbrain differentiation.

Antiviral signalling in human IPSC-derived neuronsrecapitulates neurodevelopmental disorder phenotypes

The paper shows that IFN-gamma treatment of hIPSC-derived neurons increases neurite outgrowth and alters risk gene expression, mimicking neurodevelopmental disorder features.

Brain-synthesized estrogens regulate cortical migration in a sexually divergent manner

This study shows that brain-synthesized estrogens affect cortical neuron migration differently in male and female mice through Cyp19a1 knockdown.

Estradiol reverses excitatory synapse loss in a cellular model of neuropsychiatric disorders

This study shows that estradiol restores dendritic spine density in a cellular model of schizophrenia and depression by modulating DISC1 function and synaptic protein distribution.

Schizophrenia risk from locus-specific human endogenous retroviruses

The paper identifies 148 HERVs associated with schizophrenia risk using comprehensive annotation and RNA-sequencing data from brain samples.

EPAC2 is required for corticotropin-releasing hormone-mediated spine loss

This study shows that EPAC2 is required for CRH-induced dendritic spine loss in cortical neurons.

Psychiatric risk gene NT5C2 regulates protein translation in human neural progenitor cells

This study identifies NT5C2 as a psychiatric risk gene, showing its role in protein translation and AMPK signaling in neural progenitor cells and Drosophila melanogaster.

Loss of EPAC2 results in altered synaptic composition of dendritic spines and excitatory and inhibitory balance

This study shows that loss of EPAC2 alters synaptic composition and disrupts the balance between excitatory and inhibitory synapses in cortical neurons.

Δ9-tetrahydrocannabinol negatively regulates neurite outgrowth and Akt signaling in hiPSC-derived cortical neurons.

This study shows that Δ9-THC inhibits neurite outgrowth and Akt signaling in hiPSC-derived cortical neurons via CB1R activation.