Adam Pavlinek

This paper develops a human neuron-microglia tri-culture platform to study cell-cell interactions during cortical development and disease modeling.

This study examines electrophysiological development and functional plasticity in dissociated human cerebral organoids across multiple cell lines, showing increasing connectivity and plasticity over time.

This study identifies cell-type-specific DNA methylation dynamics in the human cortex across development, highlighting prenatal periods as critical for epigenomic plasticity and linking changes to neurodevelopmental disorders.

The paper examines sex differences in brain structure at birth in newborns, finding larger brain volumes in males and specific regional differences in gray and white matter volumes between sexes.

This study shows that IFN-γ exposure in human iPSC-derived neurons increases MHCI and C4A expression while decreasing synapsin I protein, suggesting a role in neurodevelopmental disorders.