Combining NeuroPainting with transcriptomics reveals cell-type-specific morphological and molecular signatures of the 22q11.2 deletion
Matthew Tegtmeyer, Dhara Liyanage, Yu Han, Kathryn B. Hebert, Ruifan Pei, Gregory P. Way, Pearl V. Ryder, Derek Hawes, Callum Tromans‐Coia, Beth A. Cimini, Anne Elizabeth Carpenter, Shantanu Singh, Ralda Nehme
The paper introduces NeuroPainting, a morphological phenotyping method, and combines it with transcriptomics to identify cell-type-specific effects of the 22q11.2 deletion on mitochondrial structure and gene expression in astrocytes.
bioRxiv · Nov 16, 2024 · PreprintNeuroscience